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A mediator lost in the war on cancer
1Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA. x4guo@ucsd.edu
Abstract:
An unexpected role for a Mediator subunit, MED12, in resistance to multiple anticancer agents is revealed by Huang et al. Loss of MED12 confers drug resistance by activating transforming growth factor b (TGF-b) signaling. Inhibition of the TGF-b pathway resensitizes cells to therapeutic drugs, suggesting a new combinatorial cancer treatment.
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