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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Published on: August 4, 2019

TIP30 directly binds p53 tumor suppressor protein in vitro

Si-Hyung Lee1, Sung-Kyu Ju, Tae-Young Lee

  • 1Biomedical Translational Research Center, Division of Convergent Biomedical Research, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea.

Molecules and Cells
|November 27, 2012
PubMed
Summary

The tumor suppressor TIP30 (30 kDa HIV-1 TAT-interacting protein) directly binds to the DNA-binding and C-terminal domains of the p53 protein. This interaction may influence p53 levels and its role in cancer suppression.

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