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Updated: May 16, 2026
05:46
Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Telaprevir/boceprevir era: from bench to bed and back
Qiuwei Pan1, Maikel P Peppelenbosch, Harry L A Janssen
1Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, 3015 CE Rotterdam, The Netherlands. q.pan@erasmusmc.nl
World Journal of Gastroenterology
|November 28, 2012
Summary
New protease inhibitors, telaprevir and boceprevir, offer improved treatment for chronic Hepatitis C virus (HCV) infection. These advancements mark a significant evolution in managing HCV patients, especially in combination therapies.
Area of Science:
- Hepatology
- Virology
- Pharmacology
Background:
- Hepatitis C virus (HCV) affects 200 million globally.
- Interferon-based therapies show suboptimal response rates.
- HCV patient management is rapidly evolving.
Purpose of the Study:
- To overview landmark studies on telaprevir and boceprevir clinical development.
- To discuss the mechanism-of-action of these serine protease inhibitors.
- To explore their potential use in HCV-positive liver transplant patients.
Main Methods:
- Review of landmark clinical studies.
- Discussion of drug mechanisms.
- Analysis of emerging concerns and future perspectives.
Main Results:
- Telaprevir and boceprevir, serine protease inhibitors, are now available.
- These drugs are approved for combination therapy in genotype 1 HCV.
- Potential applications in liver transplantation are being explored.
Conclusions:
- Telaprevir and boceprevir represent a significant advancement in Hepatitis C treatment.
- Further research is needed to address emerging concerns and optimize therapy.
- The evolving landscape of HCV management includes these new agents.
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