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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

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Overview
Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
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Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

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Related Experiment Video

Updated: May 16, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Causes and risk factors for anaphylaxis.

Margitta Worm1, Magda Babina, Stephanie Hompes

  • 1Allergy Center CharitÈ, Department of Dermatology, Venereology and Allergology, Berlin, Germany. margitta.worm@charite.de

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|November 28, 2012
PubMed
Summary

Anaphylaxis triggers vary by age, with food common in children and venom/drugs in adults. Future research aims to improve anaphylaxis data collection and risk factor identification.

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Related Experiment Videos

Last Updated: May 16, 2026

Measuring Local Anaphylaxis in Mice
07:49

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Published on: October 14, 2014

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Area of Science:

  • Immunology
  • Allergy Research
  • Epidemiology

Background:

  • Anaphylaxis is an IgE-dependent immune response involving mast cell activation and mediator release.
  • Triggers for anaphylaxis show age-dependency: food in children, venom and drugs in adults.
  • Existing anaphylaxis registries and coding systems (ICD-10) present challenges for epidemiological data collection.

Purpose of the Study:

  • To review current understanding of anaphylaxis triggers and risk factors.
  • To highlight limitations in current epidemiological data collection for anaphylaxis.
  • To identify future research directions for improving anaphylaxis management and understanding.

Main Methods:

  • Review of recent data on anaphylaxis triggers and age-dependency.
  • Analysis of the capabilities and limitations of an established anaphylaxis registry in German-speaking countries.
  • Discussion of challenges in obtaining epidemiological data due to coding systems.

Main Results:

  • Food is the primary trigger in children, while venom and drugs are more common in adults.
  • Anaphylaxis registries, while collecting trigger and treatment data, cannot provide prevalence or incidence rates.
  • Co-factors such as physical activity, infection, alcohol, and additives are relevant in specific patient groups.

Conclusions:

  • Accurate epidemiological data for anaphylaxis is currently lacking due to data collection and coding issues.
  • Future research should focus on developing a unique coding system for trigger and severity analysis.
  • Identifying co-factor mechanisms and biomarkers for risk assessment are crucial for advancing anaphylaxis research.