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Related Concept Videos

Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Adhesion01:14

Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Types of Membrane Protrusions01:28

Types of Membrane Protrusions

The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections with a...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

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Biomimetic Materials to Characterize Bacteria-host Interactions
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SVSVGMKPSPRP: a broad range adhesion peptide.

Elias Estephan1, Jérôme Dao, Marie-Belle Saab

  • 1Université Montpellier 2, Laboratoire Charles Coulomb UMR 5221, F-34095, Montpellier, France.

Biomedizinische Technik. Biomedical Engineering
|November 28, 2012
PubMed
Summary
This summary is machine-generated.

This study found that the SVSVGMKPSPRP peptide can adhere to various metallic surfaces, making it a versatile linker for material functionalization. Its broad applicability suggests potential for diverse commercial uses in nanotechnology and materials science.

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Area of Science:

  • Materials Science
  • Biotechnology
  • Surface Chemistry

Background:

  • A 12-mer peptide (SVSVGMKPSPRP) was evolved using phage display for high affinity to semiconductor surfaces.
  • The peptide sequence appeared in multiple databases and patents, suggesting broad adhesion properties.

Purpose of the Study:

  • To investigate the adhesion properties of the SVSVGMKPSPRP peptide on various inorganic substrates.
  • To evaluate its potential as a linker for surface functionalization.

Main Methods:

  • Peptide adhesion was assessed on gold, carbon nanotubes, cobalt, chrome alloy, titanium, and titanium alloy.
  • Mass spectrometry and atomic force microscopy were employed for evaluation.

Main Results:

  • The SVSVGMKPSPRP peptide demonstrated significant potential as a linker for functionalizing metallic surfaces.
  • The peptide exhibited broad-range adhesion, not specific to a single metal surface.

Conclusions:

  • The peptide's ability to adsorb on diverse inorganic surfaces opens new avenues for research and development.
  • Further determination of the SVSVGMKPSPRP peptide's affinity is crucial for potential commercial applications.