Related Experiment Video
Updated: Feb 12, 2026
05:21
Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology
Published on: May 16, 2022
3.5K
A novel microfluidic approach for monodispersed chitosan microspheres with controllable structures
Jian-Hong Xu1, Hong Zhao, Wen-Jie Lan
1The State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, 100084, Beijing, PR China. xujianhong@tsinghua.edu.cn
Advanced Healthcare Materials
|November 28, 2012
Summary
Researchers developed a simple method to create small, uniform chitosan microspheres using microfluidics. These microspheres show promise for controlled drug release and enzyme immobilization, demonstrating varied release profiles and good stability.
Area of Science:
- Biomaterials Science
- Chemical Engineering
- Drug Delivery Systems
Background:
- Chitosan microspheres are valuable for drug delivery and biocatalysis.
- Controlling microsphere size and structure is crucial for optimizing performance.
- Existing methods for microsphere fabrication can be complex or lack precise control.
Purpose of the Study:
- To develop a novel, simple, and controllable method for preparing monodispersed chitosan microspheres.
- To investigate the application of these microspheres in protein drug controlled release.
- To evaluate the efficacy of the microspheres for immobilizing lipases.
Main Methods:
- Utilized a capillary-embedded microfluidic device for microsphere fabrication.
- Combined solvent extraction and chemical crosslinking solidification techniques.
- Characterized microsphere size, structure, and properties.
Main Results:
- Successfully prepared monodispersed chitosan microspheres with controlled sizes and structures.
- Demonstrated distinct release profiles for protein drugs encapsulated within the microspheres.
- Achieved good stability when microspheres were used for lipase immobilization.
Conclusions:
- The developed microfluidic approach offers a simple and effective way to produce tailored chitosan microspheres.
- These microspheres exhibit significant potential for advanced applications in controlled drug delivery and biocatalysis.
- The structural control achieved is key to modulating release kinetics and enzyme stability.
More Related Videos
Related Concept Videos
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
475
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
475
01:20Frustration and Conflict: Approach-Approach, Approach-Avoidance
544
Frustration occurs when people are obstructed or prevented from achieving a desired goal or fulfilling a perceived need. For example, when someone's input is ignored in a discussion, it can lead to feelings of frustration. Conflict, however, arises from opposing interests, goals, or actions. Conflicts can take various forms based on the nature of these opposing desires or goals.
One common type of conflict is the Approach–Approach Conflict. In this case, a person faces two desirable...
One common type of conflict is the Approach–Approach Conflict. In this case, a person faces two desirable...
544
02:22Structures of Solids
18.2K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
18.2K
02:34Structural Isomerism
21.7K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
21.7K
03:38Structure of Lipids
99.2K
Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
99.2K
01:21Control System Problem
443
In an open-loop system, such as a basic thermostat, the poles of the transfer function influence the system's response but do not determine its stability. However, when feedback is introduced to form a closed-loop system, such as an advanced thermostat that adjusts heating based on room temperature, stability is governed by the new poles of the closed-loop transfer function.
When forming a closed-loop system, issues can arise if the poles cross into the unstable region, leading to potential...
When forming a closed-loop system, issues can arise if the poles cross into the unstable region, leading to potential...
443