Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 16, 2026

Preparation of Mechanically Stable Self-Assembled Peptides Hydrogels

Preparation of Mechanically Stable Self-Assembled Peptides Hydrogels

Published on: September 6, 2024

Rational molecular design of complementary self-assembling peptide hydrogels.

Stuart Kyle¹, Susan H Felton, Michael J McPherson

¹Institute of Medical & Biological Engineering, Institute of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.

Advanced Healthcare Materials

|November 28, 2012

Summary

Scientists designed self-assembling peptide hydrogels for healthcare. Complementary charged sequences influence material properties, impacting biomaterial applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ozone as a Next-Generation Sterilization Process in Tissue Engineering and Regenerative Medicine: Critically Bridging Product Stability, Safety and Clinical Translation.

Molecules (Basel, Switzerland)·2026

Same author

Nanotechnology-based strategies for ROS-mediated anticancer and antimicrobial therapies.

Journal of controlled release : official journal of the Controlled Release Society·2026

Same author

Contact-Dependent Antibacterial Performance of Silver Nanoparticles Encapsulated in Collagen-Based Gels.

Journal of functional biomaterials·2026

Same author

The development of a risk threshold to aid risk stratified approach to monitoring for haematological, hepatic and/or renal adverse drug reactions during established cs DMARD treatment for systemic autoimmune rheumatic diseases: a RAND/UCLA Appropriateness Method consensus study.

Rheumatology (Oxford, England)·2026

Same author

The Ramp to Nowhere: When hope slips through the cracks in care.

The Lancet. Respiratory medicine·2025

Same author

The 2025 British Society for Rheumatology guideline for the prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs.

Rheumatology (Oxford, England)·2025

Area of Science:

Biomaterials Science
Molecular Engineering
Nanotechnology

Background:

Self-assembling peptide-based materials offer significant potential in diverse healthcare applications.
Hydrogel formation is a key characteristic for advanced biomaterial development.
Understanding molecular design is crucial for controlling material properties.

Purpose of the Study:

To rationally design self-assembling peptide-based materials that form self-supporting hydrogels.
To investigate the influence of complementary charged sequences on hydrogel properties.
To evaluate the impact of these charged interactions on biomaterial applications.

Main Methods:

Development of binary peptides utilizing complementary charged sequences.
Application of biophysical analysis techniques to characterize material properties.

More Related Videos

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Related Experiment Videos

Last Updated: May 16, 2026

Preparation of Mechanically Stable Self-Assembled Peptides Hydrogels

Preparation of Mechanically Stable Self-Assembled Peptides Hydrogels

Published on: September 6, 2024

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Utilization of cell-based studies to assess the biological performance and impact.

Main Results:

Successful rational design of peptide-based materials capable of spontaneous hydrogel formation.
Demonstration that charged interactions significantly influence the structural and mechanical properties of the peptide hydrogels.
Evidence that these modulated properties affect the suitability and performance in biomaterial applications.

Conclusions:

Rational molecular design of self-assembling peptides is effective for creating functional hydrogels.
Complementary charged sequences are a critical factor in tuning peptide hydrogel characteristics.
These findings provide a foundation for developing advanced peptide-based biomaterials for healthcare.