Study of the release process of drugs: suppositories of paracetamol

The release process of paracetamol, formulated in suppositories, prepared with four different Suppocire masses (AM, AML, AS2X and AP), having different hydrophilia, supplied by Gattefossé, was investigated. The release study of paracetamol was carried out "in vitro" by means of the Dissotest apparatus (Sotax), built on the base of the flow-through method. The assay conditions were: pH 7.4 and flow rate of 20 ml/min. The release process was evaluated using the following amodelistic parameters: the mean dissolution time (MDT), the variance of dissolution time (VDT), the dissolution efficiency (DE) and the maximum amount dissolved determined experimentally (Qmax). The amodelistic parameters, after their statistical analysis by the Kruskal-Wallis test, followed by the comparison between data pairs by the Mann-Whitney "U" test, proved that there are significant differences (p less than 0.05), with the exception of Qmax, between the four masses tested. This study shows that the masses which have a surfactant in their composition (AS2X and AP) offer a better release of paracetamol than those which have no surfactant (AM and AML).