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Updated: Aug 14, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
Study of cell surface antigens induced by herpes simplex virus. Note II. Some properties of the antigens
Abstract:
Surface antigens induced by herpes simplex virus infection in HeLa cells remain unaltered after treatment of the cells with 2% formalin for 10 min or with 0.08% trypsin for 15 min at 37 degrees C. A longer trypsin treatment (for 1 hour) will cause gradual alterations in the virus-induced antigens. Hence, these antigens are proteins deeply implanted within the cellular membrane. Their mobility--optimal at 37 degrees C--allows aggregation of the antigens in the form of caps or patches by polyvalent ligands such as IgG.
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