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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Related Experiment Video

Updated: May 16, 2026

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Prospects for stem cell-derived therapy in stroke.

John D Sinden1, Indira Vishnubhatla, Keith W Muir

  • 1ReNeuron Limited, Surrey Research Park, Guildford, Surrey, UK. john-sinden@reneuron.com

Progress in Brain Research
|November 29, 2012
PubMed
Summary
This summary is machine-generated.

Stem cell therapy for stroke shows promise, with multiple products in clinical trials. Further research is needed to optimize cell type, delivery, and patient selection for effective stroke treatment.

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Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
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Related Experiment Videos

Last Updated: May 16, 2026

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
06:12

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain

Published on: January 27, 2022

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Clinical Trials

Background:

  • Stem cell-derived therapies offer potential for treating ischemic stroke.
  • Numerous cell therapy products from various tissues are in early clinical development.

Purpose of the Study:

  • To review current cell therapy products and strategies for ischemic stroke.
  • To update on preclinical research and discuss future clinical advancements.

Main Methods:

  • Analysis of ongoing and completed clinical trials for stem cell therapy in stroke.
  • Review of preclinical research findings relevant to stroke cell therapy.

Main Results:

  • Eight clinical trials have reported final results, with many more recruiting or pending.
  • Products demonstrating safety are progressing to larger efficacy studies.

Conclusions:

  • Advancing cell therapy for stroke requires resolving key issues like cell type, timing, delivery, dosage, and patient selection.
  • Continued research and development are vital for establishing cell therapy as a future therapeutic option for ischemic stroke.