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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

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Related Experiment Video

Updated: May 16, 2026

Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
10:43

Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

Surface plasmon resonance imaging for nucleic acid detection.

Roberta D'Agata1, Giuseppe Spoto

  • 1Dipartimento di Scienze Chimiche, Università di Catania, Catania, Italy.

Analytical and Bioanalytical Chemistry
|November 29, 2012
PubMed
Summary

Surface plasmon resonance imaging (SPRI) offers a simple, fast, and cost-effective method for detecting nucleic acids like DNA and RNA. Recent advancements focus on enhancing SPRI

Area of Science:

  • Biotechnology
  • Biosensing
  • Molecular Diagnostics

Background:

  • Surface plasmon resonance imaging (SPRI) is a key technology for nucleic acid detection.
  • Existing SPRI methods aim for improved sensitivity and specificity.
  • Direct detection of DNA and RNA using SPRI is an active research area.

Purpose of the Study:

  • To review recent developments in SPRI platforms and assays.
  • To highlight advances in SPRI signal enhancement techniques.
  • To provide an overview of the current state-of-the-art in SPRI for nucleic acid detection.

Main Methods:

  • Review of recent scientific literature on SPRI technology.
  • Analysis of platform and assay developments.
  • Focus on signal enhancement strategies for SPRI.

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A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
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A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Related Experiment Videos

Last Updated: May 16, 2026

Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
10:43

Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas

Published on: July 21, 2023

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
09:09

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Main Results:

  • SPRI is a versatile tool for nucleic acid detection.
  • Significant progress has been made in enhancing SPRI sensitivity and specificity.
  • New platforms and assays are continually being developed.

Conclusions:

  • SPRI technology continues to evolve, offering improved capabilities for DNA and RNA detection.
  • Advances in signal enhancement are crucial for pushing the boundaries of SPRI sensitivity.
  • The field is moving towards more direct, sensitive, and specific nucleic acid detection methods.