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Novel therapy for type 1 diabetes: autologous hematopoietic stem cell transplantation

Lirong Li1, Weiqiong Gu, Dalong Zhu

  • 1Division of Endocrinology, The Affiliated Drum Tower Hospital of Nanjing University, Nanjing, China.

Journal of Diabetes
|November 30, 2012
PubMed

Type 1 diabetes is characterized pathologically by autoimmune insulitis-related islet β-cell destruction. Although intensive insulin therapy for patients with type 1 diabetes can correct hyperglycemia, this therapy does not prevent all diabetes-related complications. Recent studies have shown that autologous hematopoietic stem cell transplantation (HSCT) is a promising new approach for the treatment of type 1 diabetes by reconstitution of immunotolerance and preservation of islet β-cell function. Herein we discuss the therapeutic efficacy and potential mechanisms underlying the action of HSCT and other perspectives in the clinical management of type 1 diabetes.

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