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The ELAVL1-PLAUR-suPAR Axis Exacerbates Diabetic Nephropathy by Promoting Podocyte Injury and Inflammation

DanDan Xu1, Liang Xu1, LinLin Li1

  • 1Department of Nephrology, Henan Provincial People's Hospital, Zhengzhou City, Henan Province, China.

Journal of Diabetes
|August 5, 2026
PubMed
Summary

High glucose increases ELAVL1, which upregulates PLAUR and suPAR release from kidney podocytes, causing diabetic nephropathy. Targeting this ELAVL1-PLAUR-suPAR pathway may treat this kidney disease.

Keywords:
ELAVL1PLAURdiabetic nephropathypodocyte injurysuPAR

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