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Yap controls stem/progenitor cell proliferation in the mouse postnatal epidermis.

Annemiek Beverdam1, Christina Claxton, Xiaomeng Zhang

  • 1School for Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia. a.beverdam@uq.edu.au

The Journal of Investigative Dermatology
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The yes-associated protein (YAP) acts as a molecular switch for epidermal stem cell activation. YAP controls the balance between skin stem cell proliferation and differentiation, offering potential therapeutic targets for skin diseases.

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Area of Science:

  • Dermatology
  • Molecular Biology
  • Developmental Biology

Background:

  • Skin epithelium renewal relies on stem/progenitor cell activity.
  • The Hippo pathway, including its effector YAP, is crucial for stem cell regulation across species.

Purpose of the Study:

  • To investigate the role of yes-associated protein (YAP) in postnatal epidermal stem/progenitor cell activation.
  • To elucidate the function of YAP in regulating epidermal homeostasis.

Main Methods:

  • Utilized transgenic mice to overexpress a truncated YAP mutant in the basal epidermis.
  • Analyzed the effects on epidermal stem/progenitor cell populations and differentiation.

Main Results:

  • Yes-associated protein (YAP) is active in postnatal epidermal stem/progenitor cells.
  • Overexpression of a YAP mutant led to significant expansion of these cell populations.
  • The C-terminus of YAP is critical for regulating the proliferation-differentiation balance.

Conclusions:

  • Yes-associated protein (YAP) functions as a molecular switch for epidermal stem cell activation.
  • YAP plays a key role in maintaining postnatal interfollicular epidermis homeostasis.
  • YAP represents a potential therapeutic target for skin conditions like cancer, psoriasis, and epidermolysis bullosa.