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Hydrometallation-asymmetric conjugate addition: application to complex molecule synthesis

Rebecca M Maksymowicz1, Philippe M C Roth, Amber L Thompson

  • 1Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.

Chemical Communications (Cambridge, England)
|November 30, 2012
PubMed
Summary

Copper catalysis enables conjugate addition reactions using alkyl zirconium species derived from alkenes. This method efficiently synthesizes natural product enantiomers and functionalized steroids in a single step.

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