Related Experiment Video
Updated: May 16, 2026

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
Published on: September 27, 2018
Wireless capsule endoscope for targeted drug delivery: mechanics and design considerations
Stephen P Woods1, Timothy G Constandinou
1Department of Electrical and Electronic Engineering and Centre for Bio-Inspired Technology, Imperial College London, London, UK. s.woods09@imperial.ac.uk
Abstract:
This paper describes a platform to achieve targeted drug delivery in the next-generation wireless capsule endoscopy. The platform consists of two highly novel subsystems: one is a micropositioning mechanism which can deliver 1 ml of targeted medication and the other is a holding mechanism, which gives the functionality of resisting peristalsis. The micropositioning mechanism allows a needle to be positioned within a 22.5 ° segment of a cylindrical capsule and be extendible by up to 1.5 mm outside the capsule body. The mechanism achieves both these functions using only a single micromotor and occupying a total volume of just 200 mm (3). The holding mechanism can be deployed diametrically opposite the needle in 1.8 s and occupies a volume of just 270 mm (3). An in-depth analysis of the mechanics is presented and an overview of the requirements necessary to realize a total system integration is discussed. It is envisaged that the targeted drug delivery platform will empower a new breed of capsule microrobots for therapy in addition to diagnostics for pathologies such as ulcerative colitis and small intestinal Crohn's disease.
Related Concept Videos
Modified-Release Drug Delivery Systems: Site-Targeted
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Endoscopic Procedures III: Video Capsule Endoscopy
Drug Delivery: Overview
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Drug Delivery Systems: Different Types
Modified-Release Drug Delivery Systems: Overview
