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A 1024-Channel Simultaneous Electrophysiological and Electrochemical Neural Recording System With In-Pixel
IEEE Transactions on Biomedical Circuits and Systems
|September 13, 2024
Summary
This study introduces a 1024-channel lab-on-CMOS system for simultaneous neural recording. The novel design suppresses interference, enabling high-resolution electrophysiological and electrochemical data acquisition.
Area of Science:
- Neuroscience
- Electrical Engineering
- Materials Science
Background:
- Simultaneous electrophysiological and chemical recording offers multi-modal neural insights.
- Inter-modal interference limits synchronized, high-resolution neural recording systems.
Purpose of the Study:
- To develop a 1024-channel lab-on-CMOS system for dual-modal neural recording.
- To address inter-modal interference in large-scale neural instrumentation.
Main Methods:
- Implemented in-pixel digitization and interference suppression.
- Utilized a foreground calibration scheme with tunable capacitance for crosstalk compensation.
- Designed active pixels with pulse width modulation (PWM) analog-to-digital conversion for electrical and chemical modalities.
Main Results:
- Developed a 33 mm² prototype using 180 nm CMOS technology with 1024 pixels.
- Each pixel features one electrical and two chemical recording sites (150 µm × 130 µm).
- Achieved low power consumption (19.68 mW) and demonstrated concurrent high-density electrophysiological and electrochemical recording with sub-millisecond temporal resolution.
Conclusions:
- The lab-on-CMOS system successfully enables simultaneous, high-density neural recording.
- In-pixel interference suppression and calibration are effective for dual-modal neural instrumentation.
- The technology provides a powerful tool for studying neural activity with enhanced temporal and spatial resolution.
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