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Related Experiment Video

Updated: May 16, 2026

Precision Induction and Distinction of Coughing and Sneezing Reflexes in Mice
09:30

Precision Induction and Distinction of Coughing and Sneezing Reflexes in Mice

Published on: October 3, 2025

When sneezing indicates the cell type.

Matteo Gelardi1, Nicola Quaranta, Giovanni Passalacqua

  • 1Section of Otolaryngology, Department of Neuroscience and Sensory Organs, University of Bari, Bari, Italy. gelardim@inwind.it

International Forum of Allergy & Rhinology
|November 30, 2012
PubMed
Summary
This summary is machine-generated.

A "volley of sneezes" during nasal endoscopy indicates hyperreactivity. This sign is highly sensitive and specific for diagnosing nonallergic cellular rhinitis.

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Area of Science:

  • Otolaryngology
  • Allergology
  • Immunology

Background:

  • Nasal hyperreactivity is a key symptom of vasomotor rhinitis.
  • A
  • volley of sneezes
  • during nasal endoscopy is a notable clinical sign.
  • This study investigates the link between this reaction and specific clinical/cytological profiles.

Purpose of the Study:

  • To describe the
  • volley of sneezes
  • reflex during nasal endoscopy.
  • To assess the correlation between nasal hyperreactivity and clinical/cytological conditions.
  • To evaluate the diagnostic value of this sign for nonallergic rhinitis.

Main Methods:

  • 671 rhinological subjects underwent medical histories, skin prick tests, nasal endoscopy, and nasal cytology.
  • Nasal hyperreactivity, specifically the
  • volley of sneezes
  • reflex, was monitored during and after endoscopy.
  • Data were analyzed to identify correlations with rhinitis types and cytology.

Main Results:

  • 17.1% of patients exhibited hyperreactivity signs during endoscopy.
  • Hyperreactivity was significantly higher in nonallergic rhinitis subtypes: NARMA (70.6%), NARESMA (76%), and NARES (83%).
  • Allergic rhinitis patients showed increased hyperreactivity during pollen season (87.5%) versus off-season (12%).

Conclusions:

  • The
  • volley of sneezes
  • reflex is a valuable sign in nasal symptomatology.
  • This sign demonstrates high sensitivity (79%) and specificity (93%) for nonallergic cellular rhinitis.