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Published on: June 7, 2017

ViralZone: recent updates to the virus knowledge resource.

Patrick Masson1, Chantal Hulo, Edouard De Castro

  • 1SIB Swiss Institute of Bioinformatics, Swiss-Prot Group, Centre Médical Universitaire, CH-1211 Geneva 4, Switzerland.

Nucleic Acids Research
|November 30, 2012
PubMed
Summary
This summary is machine-generated.

ViralZone offers a comprehensive virus knowledge base with detailed fact sheets and linked proteomes. A new update introduces viral ontology pages for common replication steps, enhancing navigation and understanding of virus-host interactions.

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Last Updated: May 16, 2026

Rescue and Characterization of Recombinant Virus from a New World Zika Virus Infectious Clone
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Published on: June 7, 2017

Virus Propagation and Cell-Based Colorimetric Quantification
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Published on: April 7, 2023

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Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

Area of Science:

  • Virology
  • Bioinformatics
  • Molecular Biology

Background:

  • ViralZone is a valuable resource for virus information, including structure, replication, and host interactions.
  • Existing content is organized into viral fact sheets linked to UniProtKB proteomes.

Purpose of the Study:

  • To enhance the ViralZone knowledge repository by integrating a novel viral ontology.
  • To improve user navigation and understanding of common viral replication cycle steps across different viral genera.

Main Methods:

  • Development of 133 new viral ontology pages detailing common viral replication steps.
  • Integration of this ontology into UniProtKB as annotated keywords.
  • Establishing linked views between ontology, viral genera, and UniProtKB protein records.

Main Results:

  • A linked view of viral molecular biology is now available through the new ontology pages.
  • Users can seamlessly navigate from replication events to specific viral genera and associated proteins in UniProtKB.
  • The ontology facilitates a deeper understanding of shared viral replication mechanisms.

Conclusions:

  • The updated ViralZone, with its integrated viral ontology, significantly enhances the study of virus molecular biology.
  • This resource provides a powerful tool for exploring virus-host interactions and common replication strategies.