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The prognostic value of p53, Bcl-2 and Bax expression in laryngeal cancer

Pleumjit Boonyaphiphat¹, Kowit Pruegsanusak, Paramee Thongsuksai

¹Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet

|December 1, 2012

Abstract

Objective:

Determine the prognostic value of p53, Bcl-2 and Bax expression in cancer of the larynx.

Material And Method:

Ninety-four patients diagnosed with laryngeal squamous cell carcinoma were analyzed for 5-year overall survival in relation to immunohistochemical expression of p53, Bcl-2, and Bax proteins.

Results:

The present study included 86 males and eight females with a mean age of 65.1 years. Half of the patients (51%) were in stages III and IV. Radiation (44.7%) and radiation plus surgery (40.4%) were the main treatments. The frequency of p53, Bcl-2, and Bax expression was 58.1%, 18.5%, and 87.2%, respectively. The 5-year overall survival rate was 49.7%. Univariate analysis revealed that T-stage, N-stage and treatment were significantly associated with 5-year overall survival. In the multivariate Cox regression, T-stage, treatment, and Bcl-2 expression were significantly associated with survival. Positive Bcl-2 expression was associated with better survival (Hazard ratio 0.23, 95% CI 0.06-0.81).

Conclusion:

The positive Bcl-2 expression is an independent prognostic marker in laryngeal squamous cell carcinoma.

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