Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...

Synthesis and Functions of Calcitonin

Synthesis and Functions of Calcitonin

Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...

Urinary Tract Calculi I: Introduction

Urinary Tract Calculi I: Introduction

Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...

Skeleton and Calcium Homeostasis

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Obstacles in wound healing].

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti·2013

Same author

[Prevention of pressure ulcer (bedsore)].

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti·2013

Same author

[Toilet of chronic wound].

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti·2013

Same author

[Debridement- crucial procedure in the treatment of chronic wounds].

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti·2013

Same author

[Setting of compression therapy].

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti·2013

Same author

[Modern wound dressings].

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti·2013

Same journal

[CHARACTERISTIC FEATURES OF PRESSURE ULCER INFECTION].

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti·2017

Same journal

[PERSONALIZED APPROACH TO PATIENT WITH CHRONIC WOUND IN FAMILY MEDICINE].

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti·2017

Same journal

[APPLICATION OF TOPICAL HEMOGLOBIN SPRAY IN INFECTED POSTTRAUMATIC AND POSTOPERATIVE WOUNDS].

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti·2017

Same journal

[APPLICATION OF NEGATIVE PRESSURE THERAPY].

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti·2017

Same journal

[PATIENTS WITH PRESSURE ULCERS IN THE UNIFIED EMERGENCY ADMISSION DEPARTMENT – OUR REALITY].

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti·2017

Same journal

[Proposition of algorhythm for treatment with hyperbaric oxygenation Hyperbaric oxygenation in Rijeka Clinical Hospital Center].

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti·2017

See all related articles

Search research articles

Related Experiment Video

Updated: May 16, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

[Calciphylaxis].

Ciril Triller¹, Dubravko Huljev, Dragica Majasmrke

¹Ljubljana University Hospital Center, University Department of Surgery, Division of Surgical Infections, Ljubljana, Slovenia.

Acta Medica Croatica : Casopis Hravatske Akademije Medicinskih Znanosti

|December 1, 2012

Summary

This summary is machine-generated.

Calciphylaxis is a rare condition causing calcium deposits and thrombosis, leading to tissue necrosis. This case study details identifying and treating severe leg ulcers in a polymorbid patient with calciphylaxis.

More Related Videos

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

Related Experiment Videos

Last Updated: May 16, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

Area of Science:

Vascular Medicine
Dermatology
Nephrology

Background:

Calciphylaxis is a severe condition involving extra-skeletal calcification and vascular thrombosis.
It leads to tissue ischemia, skin necrosis, and can affect subcutaneous adipose tissue and skeletal muscle.
The exact cause of calciphylaxis remains unknown, but it is associated with uremia, hepatic insufficiency, obesity, and diabetes mellitus.

Observation:

This study presents a clinical case of a polymorbid patient with recognized calciphylaxis.
The patient exhibited major ulcerations on both lower legs, indicative of skin necrosis.
The condition resulted in consequential chronic leg ulcers.

Findings:

The authors detail the identification and treatment procedures for the patient's severe leg ulcerations.
The case highlights the challenges in managing calciphylaxis-induced skin necrosis.
Successful management involved addressing the underlying polymorbidity and localized wound care.

Implications:

This case underscores the importance of early recognition and multidisciplinary management of calciphylaxis.
Effective treatment strategies are crucial for improving patient outcomes and quality of life.
Further research is needed to elucidate the pathophysiology and develop targeted therapies for calciphylaxis.