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Updated: May 16, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Lupus erythematosus: a short account
L Feller1, M H Motswaledi, R Chandran
1Department of Periodontology and Oral Medicine, School of Oral Health Sciences, Faculty of Health Sciences, University of Limpopo, Medunsa Campus, South Africa. Ifeller@ul.ac.za
Abstract:
Lupus erythematosus is a chronic autoimmune inflammatory disease with diverse clinical manifestations including arthritis, skin disorders and kidney disease. Pathologically it is characterised by complex interactions between multiple genetic, epigenetic and extraneous factors; and serologically by the presence of a variety of antibodies which are reactive to intracellular molecular constituents. Impaired clearance of apoptotic cells and of immune complexes, loss of immune tolerance to self-antigens and dysregulation of the cytokine network act synergistically with extraneous factors such as ultraviolet radiation, viruses and certain drugs to induce and sustain lupus erythematosus.
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