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Updated: May 16, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Lupus erythematosus: a short account
L Feller1, M H Motswaledi, R Chandran
1Department of Periodontology and Oral Medicine, School of Oral Health Sciences, Faculty of Health Sciences, University of Limpopo, Medunsa Campus, South Africa. Ifeller@ul.ac.za
Summary
Lupus erythematosus is a chronic autoimmune disease affecting multiple organs. Its development involves genetic, epigenetic, and environmental factors, leading to self-reactive antibodies and immune system dysregulation.
Area of Science:
- Immunology
- Rheumatology
- Genetics
Background:
- Lupus erythematosus is a chronic autoimmune inflammatory disease.
- It presents with diverse clinical manifestations like arthritis, skin, and kidney disease.
- Pathology involves complex interactions of genetic, epigenetic, and environmental factors.
Purpose of the Study:
- To summarize the pathological and serological characteristics of lupus erythematosus.
- To elucidate the synergistic factors contributing to lupus pathogenesis.
- To highlight the role of immune system dysregulation in lupus.
Main Methods:
- Review of pathological and serological findings in lupus erythematosus.
- Analysis of genetic, epigenetic, and environmental influences.
- Examination of immune system components like antibodies, apoptotic cell clearance, and cytokine networks.
Main Results:
- Serologically, lupus is characterized by antibodies reactive to intracellular molecules.
- Impaired clearance of apoptotic cells and immune complexes contributes to the disease.
- Loss of immune tolerance and cytokine network dysregulation are key pathological features.
Conclusions:
- Lupus pathogenesis is multifactorial, involving genetic predisposition and environmental triggers.
- Immune system dysregulation, including autoantibody production and impaired clearance mechanisms, is central to lupus.
- Ultraviolet radiation, viruses, and drugs can synergistically induce and sustain lupus erythematosus.
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