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Introducing ligand-based hydrogen bond donors to a receptor: both selectivity and binding affinity for anion
Feihu Huang1, Chen Cheng, Guoqiang Feng
1Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University,152 Luoyu Road, Wuhan 430079, P. R. China.
Abstract:
Introducing hydrogen bond donors to a receptor was found to be an effective approach to improve both its selectivity and binding affinity for pyrophosphate in water. The crystal structure of Zn3-ADP complex showed the improvements come from the combination of H-bonding and metal coordination in a manner similar to many metalloenzymes.
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