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Changes in urine composition after trauma facilitate bacterial growth
Cecile Aubron1, Olivier Huet, Sylvie Ricome
1Site Xavier Bichat, INSERM U722 and Université Paris 7 Denis Diderot, 16 rue Henri Huchard, Paris 75018, France. cecile.aubron@free.fr
BMC Infectious Diseases
|December 1, 2012
Summary
Urine from trauma patients significantly enhances Escherichia coli growth compared to healthy individuals, potentially contributing to urinary tract infections (UTIs) in critically ill patients.
Area of Science:
- Urology
- Infectious Diseases
- Critical Care Medicine
Background:
- Critically ill patients, including trauma survivors, face a high risk of urinary tract infections (UTIs).
- Urine composition in trauma patients can be altered by inflammation, systemic stress, rhabdomyolysis, and medical interventions.
Purpose of the Study:
- To investigate whether urine from severe trauma patients promotes the growth of Escherichia coli (E. coli).
- To compare E. coli growth in urine from trauma patients versus healthy volunteers.
- To identify potential urinary compositional changes influencing bacterial growth.
Main Methods:
- Prospective, single-centre observational study.
- Collected 24-hour urine samples from severe trauma patients and healthy volunteers on days 1 and 5 post-trauma.
- Compared E. coli growth and analyzed biochemical/hormonal urine modifications.
Main Results:
- E. coli growth was significantly higher in urine from trauma patients on both days 1 and 5 compared to healthy volunteers.
- Trauma patients exhibited increased glycosuria, urine iron concentration, and amino acid levels.
- Lower urinary osmotic pressure was observed in trauma patients on day 1.
Conclusions:
- Trauma patient urine facilitates E. coli growth, an effect observed from day 1 up to at least day 5 post-trauma.
- These urinary modifications may play a role in the pathophysiology of UTIs in trauma patients.
- Further research is needed to pinpoint the specific causative factors.
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