Related Experiment Video

Updated: May 16, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Acute prognostic factors for post-thrombotic syndrome in children with limb DVT: a bi-institutional cohort study

Courtney A Lyle1, Elizabeth Gibson, Amy E Lovejoy

  • 1Department of Pediatrics, Division of Hematology/Oncology, University of California San Diego and Rady Children's Hospital, San Diego, CA, USA. clyle@billingsclinic.org

Thrombosis Research
|December 1, 2012
PubMed

Insights

Early identification of pediatric deep venous thrombosis (DVT) risk factors is crucial. A positive lupus anticoagulant test (dRVVT) within two weeks of DVT diagnosis significantly increases the risk of post-thrombotic syndrome (PTS) in children.

Area of Science:

  • Pediatric Thrombosis and Hemostasis
  • Vascular Medicine
  • Clinical Outcomes Research

Background:

  • Early identification of children at high risk for post-thrombotic syndrome (PTS) after deep venous thrombosis (DVT) is critical for evaluating interventions.
  • Understanding acute prognostic factors for PTS in pediatric limb DVT is essential.

Purpose of the Study:

  • To evaluate acute prognostic factors for the development of PTS in children diagnosed with limb DVT.

Main Methods:

  • A bi-institutional mixed cohort study with prospective PTS ascertainment using a validated pediatric instrument.
  • Data collected included patient/thrombus characteristics, thrombophilia testing, and outcomes in children (<21 years) with acute limb DVT.

Main Results:

  • The cumulative incidence of PTS was 23% at a median follow-up of 33 months.
  • A positive lupus anticoagulant (by dilute Russell Viper venom time - dRVVT) within two weeks of DVT diagnosis was associated with significantly increased odds of clinically significant PTS (OR: 16.8, P=0.02).
  • Infectious or inflammatory conditions at presentation were not associated with PTS risk or dRVVT positivity.

Conclusions:

  • An acutely positive dRVVT test after limb DVT diagnosis is a significant prognostic factor for clinically significant PTS in children.
  • Larger studies are needed to confirm these findings and explore persistent dRVVT positivity or beta-2-glycoprotein-I dependence.
Abstract

More Related Videos

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis06:45

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Pulmonary Embolism III: Nursing Management01:27

Pulmonary Embolism III: Nursing Management

A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...