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Updated: May 16, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Environmental pH-sensitive polymeric micelles for cancer diagnosis and targeted therapy
Guang Hui Gao1, Yi Li, Doo Sung Lee
1Department of Polymer Science and Engineering, Theranostic Macromolecules Research Center, Sungkyunkwan University, Suwon, Republic of Korea.
Abstract:
The delivery and control over the release of hydrophobic imaging markers for cancer diagnosis or pharmaceutical agents for targeted therapy are of considerable interest. Nano-sized pH-sensitive polymeric micelles that rely on the enhanced permeability and retention (EPR) of vasculature and the low-pH microenvironment in cancer tissue are emerging as stimuli-responsive targeted therapies that can simultaneously release diagnostic and therapeutic agents into a cancerous region. This review focuses on the developments of pH-sensitive polymeric micelles and their biomedical applications in cancer diagnosis and targeted therapy.
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