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Related Experiment Video

Updated: May 16, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

J Dupy-Blanc¹, C A Grolière, R Berrada

¹Zoologie et Protistologie, U.A. du CNRS 138, Université Blaise-Pascal, Clermont-Ferrand, Aubière, France.

European Journal of Protistology

|December 1, 2012

Summary

This summary is machine-generated.

Antibiotics can increase macronuclear DNA content, especially in larger cells with longer generation times. Epinigericin is less toxic than nigericin, as shown by DNA labeling studies.

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Area of Science:

Cell Biology
Molecular Biology
Toxicology

Context:

Antibiotic administration can impact cellular processes.
Cellular responses to chemical agents vary.
Macronuclear DNA content is a key indicator of cell cycle progression.

Purpose:

To investigate the effect of antibiotics on macronuclear DNA content.
To compare the toxicity of nigericin and epinigericin.
To analyze DNA synthesis activity post-antibiotic exposure.

Summary:

Antibiotics induced an increase in macronuclear DNA content, linked to DNA synthesis in phase S2.
Larger cells exhibited higher DNA content and extended generation times.
Autoradiography confirmed increased DNA labeling with nigericin (46%) versus epinigericin (37%), indicating lower epinigericin toxicity.

Impact:

Provides insights into antibiotic-induced cellular changes.
Highlights differential toxicity between related compounds.
Informs understanding of cell cycle regulation under chemical stress.