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Related Experiment Video

Updated: May 16, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Hypericum for fatigue - a pilot study.

C Stevinson¹, M Dixon, E Ernst

¹Department of Complementary Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, Exeter, UK.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology

|December 1, 2012

Summary

This pilot study suggests Hypericum perforatum may effectively reduce unexplained fatigue. Further randomized controlled trials are needed to confirm these findings for fatigue treatment.

Related Experiment Videos

Last Updated: May 16, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Area of Science:

Integrative Medicine
Phytotherapy
Clinical Psychology

Background:

Fatigue is a prevalent medical complaint lacking definitive treatments.
Hypericum perforatum (St. John's Wort) shows efficacy in reducing fatigue in depressed individuals.
Unexplained fatigue warrants investigation for novel therapeutic interventions.

Purpose of the Study:

To explore the potential of Hypericum perforatum as a remedy for unexplained fatigue.
To gather preliminary data for a future randomized controlled trial.
To assess the impact of Hypericum on fatigue, depression, and anxiety symptoms.

Main Methods:

An open-label, uncontrolled pilot study.
Twenty patients with unexplained fatigue received Hypericum extract (3x1 tablet daily) for six weeks.
Fatigue, depression, and anxiety were assessed using baseline and follow-up measures.

Main Results:

Significant reduction in perceived fatigue after two weeks, with further decrease at six weeks.
Concurrent reduction in symptoms of depression and anxiety observed.
Baseline data indicated potential depression in nearly half the participants, possibly linked to fatigue.

Conclusions:

Hypericum perforatum demonstrates potential in alleviating unexplained fatigue.
Results support the need for a randomized placebo-controlled trial to validate Hypericum's specific effects on fatigue.
Future study designs should consider the comorbidity of depression in fatigue management.