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Updated: May 16, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
[Treatment of chronic migraine and medication overuse headache]
1Kitasato University School of Medicine, Department of Neurology Kitasato Institute Hospital.
Abstract:
Evidence has accumulated recently indicating biochemical, physiologic, pathophysiological alterations in the brain of patients with chronic migraine. Another type of the refractory headache for treatment is medication overuse headache. Both headaches are severely disabling and difficult to manage, as affected patients experience substantially more-frequent headaches, comorbid pain and affective disorders, and fewer pain-free intervals, than do those with episodic migraine. One principle for treatment is to stop medication of acute treatment (triptans, NSAIDs etc). Then preventive treatment must be started.
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