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Related Experiment Video

Updated: May 16, 2026

Stimulated Single Fiber Electromyography (SFEMG) for Assessing Neuromuscular Junction Transmission in Rodent Models
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Stimulated Single Fiber Electromyography (SFEMG) for Assessing Neuromuscular Junction Transmission in Rodent Models

Published on: March 8, 2024

[Reference values for concentric needle single fiber EMG].

Norito Kokubun1

  • 1Department of Neurology, Dokkyo Medical University.

Rinsho Shinkeigaku = Clinical Neurology
|December 1, 2012
PubMed
Summary
This summary is machine-generated.

Single-fiber electromyography (SFEMG) using concentric needles provides sensitive diagnosis for myasthenia gravis. This study establishes crucial reference values for Japanese subjects, aiding accurate diagnosis.

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Last Updated: May 16, 2026

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Area of Science:

  • Neurology
  • Clinical Electrophysiology

Context:

  • Single-fiber electromyography (SFEMG) is a highly sensitive diagnostic tool for myasthenia gravis.
  • Historically, single-fiber needle electrodes were used, but disposable concentric needle electrodes are increasingly employed to mitigate infection risks.

Purpose:

  • To prospectively establish reference values for concentric needle SFEMG in Japanese subjects.
  • To determine these values for both voluntary and stimulated SFEMG in the extensor digitorum communis (EDC) and frontalis (FRO) muscles.

Summary:

  • A multicenter study involving 69 healthy Japanese subjects under 60 years old was conducted.
  • Reference values for mean consecutive difference (MCD) were calculated using +2.5 SD or 95% prediction limits.
  • Recommended cut-off values for individual MCD were established for voluntary and stimulated SFEMG in EDC and FRO muscles.

Impact:

  • This research provides the first multicenter-derived reference values for SFEMG using concentric needles.
  • These established values are essential for the accurate and reliable diagnosis of myasthenia gravis in Japanese populations.
  • The findings support the standardization of SFEMG diagnostic criteria using modern, safer electrode technology.