Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacogenetics of Drug Metabolism: Overview01:27

Pharmacogenetics of Drug Metabolism: Overview

Genetic polymorphism in drug metabolism is crucial to the inter-individual variability observed in drug responses. Drug metabolism primarily involves the chemical modification of drugs and other xenobiotics to enhance their elimination by increasing their polarity. Two main classes of enzymes mediate this biotransformation process: Phase I enzymes, primarily cytochrome P450s, catalyze oxidation and reduction reactions, while other enzymes, such as esterases, mediate hydrolysis, and Phase II...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intramedullary osteoblastoma of the femur: a case report.

Skeletal radiology·2026
Same author

Validating exacerbations of asthma in electronic health records: a systematic review.

European respiratory review : an official journal of the European Respiratory Society·2026
Same author

Convolutional Neural Networks in Radiology: Principles, Clinical Applications, and a Practical Framework for Radiologists.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre·2026
Same author

"We've managed to find our own path of how we do it": exploring parental perceptions of using age-inappropriate formulations at home-a qualitative study.

Frontiers in pediatrics·2026
Same author

Metal-artefact-reduction MRI for diagnosing periprosthetic joint infection: a systematic review and meta-analysis.

Skeletal radiology·2026
Same author

Installing Air Purifiers in the Homes of Children With Severe Asthma: Outcomes and Family Perspectives From a Feasibility Study.

Pediatric pulmonology·2026
Same journal

Artificial intelligence for child health: current capabilities and the next frontier.

Archives of disease in childhood·2026
Same journal

Troubled origins and lasting impact of the first insulin injection.

Archives of disease in childhood·2026
Same journal

Paediatric readiness assessment tools in emergency care: a scoping review.

Archives of disease in childhood·2026
Same journal

Building a paediatric workforce to deliver the NHS prevention agenda: time for paediatric public health medicine?

Archives of disease in childhood·2026
Same journal

Impact of antenatal biological response modifying drugs on infant infection risk and vaccination rates: a national cohort study.

Archives of disease in childhood·2026
Same journal

Draft charter for asthma in children and young people, inspired by Martha's rule.

Archives of disease in childhood·2026
See all related articles

Related Experiment Video

Updated: May 16, 2026

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

Paediatric pharmacogenomics: an overview.

Daniel B Hawcutt1, Ben Thompson, Rosalind L Smyth

  • 1Division of Developmental and Reproductive Medicine, Women's and Children's Health, University of Liverpool, Alder Hey Children's Hospital, Eaton Road, Liverpool L12 2AP, UK. d.hawcutt@liverpool.ac.uk

Archives of Disease in Childhood
|December 1, 2012
PubMed
Summary
This summary is machine-generated.

Pharmacogenomics research is advancing, but clinical integration remains limited. Understanding pharmacogenomics is crucial for interpreting findings and implementing them into patient care, especially in pediatrics.

More Related Videos

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
06:21

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

Related Experiment Videos

Last Updated: May 16, 2026

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
06:21

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

Area of Science:

  • Genomic Medicine
  • Translational Science

Background:

  • Pharmacogenomics research is expanding in academia and industry.
  • Despite advances, clinical integration of pharmacogenomic discoveries is limited.
  • High-throughput technologies and improved study designs drive ongoing discovery of drug response determinants.

Purpose of the Study:

  • To explain the scientific basis of pharmacogenomics.
  • To describe challenges in pharmacogenomics implementation.
  • To focus on the specific challenges within pediatric pharmacogenomics.

Main Methods:

  • Review of current pharmacogenomics research landscape.
  • Explanation of core scientific principles.
  • Discussion of implementation challenges.

Main Results:

  • Pharmacogenomic discoveries continue to emerge due to technological and methodological advancements.
  • Successful clinical integration of pharmacogenomics has been limited thus far.
  • Understanding the science is key for clinical teams to interpret and apply findings.

Conclusions:

  • Continued advancements in pharmacogenomics promise further identification of drug response determinants.
  • Effective clinical implementation requires a strong understanding of the underlying science by healthcare professionals.
  • Addressing challenges, particularly in pediatrics, is essential for broader adoption of pharmacogenomics.