DNA ploidy patterns in gallbladder adenocarcinoma

DNA ploidy patterns in gallbladder carcinoma were examined by flow cytometry using paraffin-embedded tissues. The incidence of DNA aneuploidy was 46.3% and of a diploid pattern, 53.7%. No relation could be observed between DNA ploidy pattern and histological type. There was a tendency for the incidence of diploid patterns in early carcinomas to be higher than that of aneuploidy patterns, but there was no significant difference. No obvious correlation could be demonstrated between DNA ploidy pattern and prognosis. Gallbladder carcinomas were divided into metaplastic and non-metaplastic types based on the presence or absence of metaplastic changes, in accordance with our classification. The relation between DNA ploidy pattern and tumor type was examined, but none was observed. In the present study, no correlation could be observed between DNA ploidy pattern and clinicopathologic findings in gallbladder carcinoma.