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Diffuse large B-cell lymphoma in human T-lymphotropic virus type 1 carriers

Brady E Beltran1, Pilar Quiñones, Domingo Morales

  • 1Department of Oncology and Radiotherapy, Edgardo Rebagliati Martins Hospital, Lima, Peru.

Leukemia Research and Treatment
|December 1, 2012
PubMed

We describe the clinical and pathological characteristics of seven patients who were human T-lymphotropic virus type 1 (HTLV-1) carriers and had a pathological diagnosis of de novo diffuse large B-cell lymphoma. Interestingly, three of our cases showed positive expression of Epstein-Barr-virus, (EBV-) encoded RNA within the tumor cells indicating a possible interaction between these two viruses. Furthermore, our three EBV-positive cases presented with similar clinical characteristics such as early clinical stage and low-risk indices. To the best of our knowledge, this is the first case series describing the characteristics of HTLV-1-positive DLBCL patients. The potential relationship between HTLV-1 and EBV should be further explored.

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