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Affective disorder and hyperandrogenism
Celen Zerouni1, Elaine Kummerow, Mariflor Martinez
1Universidad de Carabobo, Facultad de Ciencias de la Salud, Departamento de Ciencias Fisiológicas, Valencia, Venezuela.
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
|December 4, 2012
Summary
This study suggests a link between elevated androgen hormones in women, quetiapine and lithium carbonate treatment, and affective disorders like bipolar disorder and premenstrual dysphoric disorder.
Area of Science:
- Endocrinology
- Psychiatry
- Pharmacology
Background:
- A 40-year-old female patient diagnosed with bipolar disorder and premenstrual dysphoric disorder was undergoing treatment with quetiapine and lithium carbonate.
- The patient exhibited no physical signs of virilization.
Observation:
- Initial laboratory tests revealed hyperandrogenism, with testosterone levels at 88.5 ng/dL.
- Subsequent testing showed normalized testosterone levels (free testosterone 0.20 pg/ml, total testosterone 27.90 ng/dL).
Findings:
- Following treatment control, free thyroxine (T4) levels decreased to 0.83 ng/dL, and progesterone levels increased to 3.80 ng/mL.
- The study observed a potential association between elevated androgen levels, quetiapine and lithium carbonate therapy, and the presence of affective and premenstrual dysphoric disorders.
Implications:
- This case highlights a possible connection between specific psychiatric medications and hormonal imbalances in women.
- Further research is warranted to explore the relationship between androgenic hormone levels, psychiatric conditions, and psychotropic medications.
- Understanding these interactions may inform more personalized treatment strategies for patients with co-occurring mood disorders and hormonal disturbances.
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