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Tau pathology: predictive diagnostics, targeted preventive and personalized medicine and application of advanced

Illana Gozes1

  • 1Department of Human Molecular Genetics and Biochemistry The Lily and Avraham Gildor Chair for the Investigation of Growth Factors and The Adams Super Center for Brain Studies Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978 Israel.

The EPMA Journal
|December 4, 2012
PubMed

Insights

Microtubule-associated protein tau (MAPT) is central to tauopathies like Alzheimer's disease. This review explores tau pathology variations and innovative treatments, including predictive diagnostics and personalized medicine.

Area of Science:

  • Cell Biology
  • Neuroscience
  • Pathology

Background:

  • Microtubules, essential cytoskeletal components, are regulated by microtubule-associated proteins (MAPs).
  • Tau (MAPT) is a key MAP, crucial for microtubule assembly, particularly in neurons and axons.
  • Tauopathies, including Alzheimer's disease (AD), are characterized by tau pathology and neurodegeneration.

Purpose of the Study:

  • To review the diverse manifestations of tau pathologies in various tauopathies.
  • To discuss commonalities and differences among tauopathies.
  • To highlight emerging therapeutic strategies and advanced technologies for tauopathies.

Main Methods:

  • Literature review of tauopathies and microtubule-associated protein tau (MAPT).
  • Analysis of current innovations in diagnostics and treatment for tauopathies.
  • Exploration of personalized and preventive medicine approaches.

Main Results:

  • Tau pathology variability exists across different tauopathies, with AD being the most common.
  • Tau inclusions are present in tauopathies even without beta-amyloid plaques.
  • Increased tau pathology correlates with cognitive decline in Alzheimer's disease.

Conclusions:

  • Understanding tau pathology heterogeneity is crucial for effective treatment.
  • Advanced technologies offer promise for predictive diagnostics and personalized medicine in tauopathies.
  • Targeted preventive and personalized medicine (PPPM) strategies are advancing the treatment landscape for tauopathies.

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