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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
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Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Related Experiment Video

Updated: May 16, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

[Specific immunotherapy in asthma].

N Pham-Thi1

  • 1Université Paris Descartes, CNRS U8147, service de pneumologie et allergologie, hôpital Necker-Enfants-Malades, Paris, France. Nhan.phamthi@nck.aphp.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|December 4, 2012
PubMed
Summary
This summary is machine-generated.

Specific immunotherapy (SIT) is the only treatment that can alter the course of the atopic march in children. SIT effectively improves allergic asthma outcomes and may prevent new allergic sensitizations.

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Basophil Activation Test for Allergy Diagnosis
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Published on: November 4, 2010

Area of Science:

  • Allergy and Immunology
  • Pediatric Pulmonology
  • Clinical Therapeutics

Context:

  • The atopic march describes the progression of allergic diseases in children.
  • Current treatments for allergic diseases often manage symptoms but do not alter disease progression.
  • Specific immunotherapy (SIT) offers a potential disease-modifying approach.

Purpose:

  • To evaluate the role of specific immunotherapy (SIT) in modifying the natural history of the atopic march in pediatric populations.
  • To assess the efficacy of SIT in managing allergic asthma and preventing new sensitizations.

Summary:

  • Specific immunotherapy (SIT), also known as allergenic desensitization, is identified as a unique treatment capable of altering the natural course of the atopic march in children.
  • Clinical evidence demonstrates SIT's efficacy in allergic asthma, significantly improving clinical assessments and reducing medication requirements.
  • Furthermore, SIT shows potential in preventing the development of asthma and new allergic sensitizations.

Impact:

  • SIT represents a crucial therapeutic strategy for pediatric allergic diseases, potentially altering long-term health trajectories.
  • This approach may lead to reduced disease burden and improved quality of life for children with allergies.
  • Findings support the consideration of SIT for early intervention in the atopic march.