Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Food Intake

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

Primary Motives: Hunger and Thirst

Primary Motives: Hunger and Thirst

Hunger and thirst are fundamental physiological drives crucial for maintaining homeostasis and ensuring the survival of both humans and animals. These drives are regulated through complex interactions between the brain, hormones, and sensory receptors.
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus acts...

Hormonal Regulation

Hormonal Regulation

Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.

Hormonal Regulation

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

Glucagon-like Receptor Agonists

Glucagon-like Receptor Agonists

Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...

Hormones Regulating Blood Glucose

Hormones Regulating Blood Glucose

Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Price Discounts to Promote Supermarket Fruit, Vegetable, and Noncaloric Beverage Intake and Health Outcomes: A Randomized Controlled Trial.

Journal of the Academy of Nutrition and Dietetics·2026

Same author

Increased alcohol intake and alcohol use disorder following bariatric surgery: potential mechanisms.

Physiology & behavior·2025

Same author

A moving target: Ideal body size following weight loss surgery.

Journal of health psychology·2025

Same author

A systematic review and meta-analysis of cross-sectional questionnaire studies of the relationship between negative and positive emotional eating and body mass index: Valence matters.

Appetite·2025

Same author

Dietary eggs, egg nutrients, polygenic score for body mass index, "Western pattern" diet, and weight change, a prospective analysis in the Women's health initiative.

Clinical nutrition (Edinburgh, Scotland)·2024

Same author

Effects of discounting fruits, vegetables, and noncaloric beverages in New York City supermarkets on purchasing, intake, and weight.

Obesity (Silver Spring, Md.)·2024

Search research articles

Related Experiment Video

Updated: May 16, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

Coffee, hunger, and peptide YY.

James A Greenberg¹, Allan Geliebter

¹Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, USA. jamesg@brooklyn.cuny.edu

Journal of the American College of Nutrition

|December 4, 2012

Summary

Decaffeinated coffee, not caffeine, significantly reduces hunger and increases the satiety hormone peptide YY (PYY). This suggests non-caffeine coffee components may aid in weight management.

Area of Science:

Human nutrition
Endocrinology
Metabolism

Background:

Coffee consumption is widespread, with some studies suggesting a role in body weight management.
The specific components of coffee responsible for these effects, particularly non-caffeine elements, require further investigation.
Understanding the impact of coffee on appetite regulation is crucial for developing strategies for weight control.

Purpose of the Study:

To evaluate the effects of caffeine, caffeinated coffee, and decaffeinated coffee on perceived hunger and satiety.
To assess the influence of these beverages, with and without glucose, on key appetite-regulating peptides.
To determine if non-caffeine compounds in coffee contribute to appetite control.

Main Methods:

A placebo-controlled, single-blinded, randomized 4-way crossover trial was conducted.

More Related Videos

Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell

Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell

Published on: July 19, 2015

Control of Eating Behavior Using a Novel Feedback System

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

Related Experiment Videos

Last Updated: May 16, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell

Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell

Published on: July 19, 2015

Control of Eating Behavior Using a Novel Feedback System

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

Eleven healthy male volunteers consumed test beverages (caffeine, caffeinated coffee, decaffeinated coffee, or placebo) followed by glucose.

Perceived hunger and satiety were measured using visual analog scales, and blood levels of ghrelin, peptide YY (PYY), and leptin were analyzed.

Main Results:

Decaffeinated coffee significantly reduced hunger and increased plasma PYY compared to placebo.
Caffeine alone did not affect hunger or PYY levels.
Caffeinated coffee showed intermediate effects, suggesting a role for non-caffeine components.

Conclusions:

Decaffeinated coffee acutely decreases hunger and elevates the satiety hormone PYY in humans.
These findings indicate that compounds in coffee other than caffeine may possess appetite-suppressing properties.
The study highlights the potential of decaffeinated coffee in strategies aimed at appetite regulation and weight management.