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Published on: October 2, 2018

Cladophialophora bantiana brain abscess in an immunocompetent patient

Sanjay G Revankar1

  • 1Division of Infectious Diseases, Wayne State University, Detroit, Michigan, USA.

The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Medicale
|December 4, 2012
PubMed

Insights

Cladophialophora bantiana, a fungal infection, can cause severe brain abscesses even in healthy individuals. This case highlights the high mortality rate and lack of standardized treatment for this rare mycosis.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Neurology

Background:

  • Cladophialophora bantiana is a dematiaceous mold known for causing central nervous system infections.
  • This fungus disproportionately affects immunocompetent hosts, presenting a diagnostic and therapeutic challenge.

Observation:

  • A case of a 79-year-old immunocompetent woman with left-sided weakness and a ring-enhancing brain lesion is presented.
  • Surgical excision confirmed a brain abscess caused by Cladophialophora bantiana.

Findings:

  • Despite treatment with liposomal amphotericin B, voriconazole, and flucytosine, the patient succumbed to the infection.
  • This case underscores the high mortality associated with C. bantiana brain infections, even in immunocompetent individuals.

Implications:

  • Current therapeutic strategies for C. bantiana mycosis are not standardized.
  • Further research into the pathogenesis and effective treatment of C. bantiana infections is crucial to improve patient outcomes.
Keywords:
Brain abscessCladophialophora bantianaFlucytosineLiposomal amphotericin BPhaeohyphomycosisVoriconazole

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