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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

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MicroRNAs and lymphomagenesis: a functional review

Charles H Lawrie1

  • 1Biodonostia Research Institute, San Sebastián, Spain. charles.lawrie@biodonostia.org

British Journal of Haematology
|December 5, 2012
PubMed

Insights

MicroRNAs (miRNAs) play a key role in gene regulation and cancer. This review highlights specific miRNAs with confirmed functional roles in the pathogenesis of common lymphomas, supported by animal models.

Area of Science:

  • Molecular Biology
  • Oncology
  • Gene Regulation

Background:

  • MicroRNAs (miRNAs) represent a crucial layer of gene expression control impacting numerous biological processes.
  • Aberrant miRNA expression is a hallmark of many cancers, including lymphomas.
  • While the identity of dysregulated miRNAs in lymphomas is known, their functional roles in lymphomagenesis are less understood.

Purpose of the Study:

  • To review miRNAs with experimentally confirmed functional roles in the pathogenesis of common lymphoma types.
  • To highlight specific miRNA clusters and individual miRNAs implicated in lymphomagenesis.

Main Methods:

  • Literature review focusing on miRNAs with experimentally validated functions in lymphoma.
  • Emphasis on studies providing in vivo animal model evidence for miRNA involvement.

Main Results:

  • The MIR15A/16-1 cluster, MIR21, MIR155, MIR17HG (MIR17-92 cluster), MIR34A, and MIR125B are identified as key players.
  • These miRNAs have demonstrated involvement in lymphomagenesis through in vivo animal studies.

Conclusions:

  • Specific miRNAs, including MIR15A/16-1, MIR21, MIR155, MIR17HG, MIR34A, and MIR125B, possess experimentally confirmed functional roles in lymphoma development.
  • Further research into these miRNAs can elucidate mechanisms of lymphomagenesis and identify therapeutic targets.

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