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Updated: May 16, 2026
07:23
Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
Published on: June 15, 2016
MicroRNAs and lymphomagenesis: a functional review
1Biodonostia Research Institute, San Sebastián, Spain. charles.lawrie@biodonostia.org
British Journal of Haematology
|December 5, 2012
Summary
MicroRNAs (miRNAs) play a key role in gene regulation and cancer. This review highlights specific miRNAs with confirmed functional roles in the pathogenesis of common lymphomas, supported by animal models.
Area of Science:
- Molecular Biology
- Oncology
- Gene Regulation
Background:
- MicroRNAs (miRNAs) represent a crucial layer of gene expression control impacting numerous biological processes.
- Aberrant miRNA expression is a hallmark of many cancers, including lymphomas.
- While the identity of dysregulated miRNAs in lymphomas is known, their functional roles in lymphomagenesis are less understood.
Purpose of the Study:
- To review miRNAs with experimentally confirmed functional roles in the pathogenesis of common lymphoma types.
- To highlight specific miRNA clusters and individual miRNAs implicated in lymphomagenesis.
Main Methods:
- Literature review focusing on miRNAs with experimentally validated functions in lymphoma.
- Emphasis on studies providing in vivo animal model evidence for miRNA involvement.
Main Results:
- The MIR15A/16-1 cluster, MIR21, MIR155, MIR17HG (MIR17-92 cluster), MIR34A, and MIR125B are identified as key players.
- These miRNAs have demonstrated involvement in lymphomagenesis through in vivo animal studies.
Conclusions:
- Specific miRNAs, including MIR15A/16-1, MIR21, MIR155, MIR17HG, MIR34A, and MIR125B, possess experimentally confirmed functional roles in lymphoma development.
- Further research into these miRNAs can elucidate mechanisms of lymphomagenesis and identify therapeutic targets.
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