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B regulatory cells in cancer
Frances Balkwill1, Anne Montfort, Melania Capasso
1Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK. f.balkwill@qmul.ac.uk
Trends in Immunology
|December 5, 2012
Summary
B regulatory cells are a newly identified B cell subtype. This review explores their role in autoimmunity and cancer, focusing on evidence that these cells promote tumor growth.
Area of Science:
- Immunology
- Oncology
Background:
- B regulatory cells (Bregs) are an emerging subpopulation of B lymphocytes.
- Bregs have been implicated in the pathogenesis of autoimmune diseases.
Purpose of the Study:
- To review current knowledge on B regulatory cells.
- To summarize evidence for the role of B cells, particularly Bregs, in promoting tumor growth.
Main Methods:
- Literature review of studies on B regulatory cells and cancer immunology.
Main Results:
- B regulatory cells are involved in immune regulation.
- Growing evidence suggests B regulatory cells contribute to tumor progression.
Conclusions:
- B regulatory cells represent a significant factor in cancer development.
- Further research into B regulatory cells may offer novel therapeutic strategies for cancer.
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