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Endobronchial involvement in non-Hodgkin lymphoma
Emine Argüder1, Hatice Canan Hasanoğlu, Ayşegül Karalezli
1Department of Chest Diseases, Ankara Atatürk Training and Research Hospital, Bilkent Street, Ankara, Turkey. drgullu2000@gmail.com
Journal of Bronchology & Interventional Pulmonology
|December 5, 2012
Summary
Endobronchial Non-Hodgkin lymphoma, a rare condition, presented in a patient with persistent cough and dyspnea. Treatment with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) led to significant lesion resolution.
Area of Science:
- Pulmonology
- Oncology
- Pathology
Background:
- Non-Hodgkin lymphoma commonly involves the thorax, but endobronchial involvement is infrequent.
- This case highlights a rare presentation of Non-Hodgkin lymphoma within the airways.
Observation:
- A 65-year-old male presented with a two-month history of refractory cough and progressive dyspnea.
- Imaging revealed bilateral lower lobe infiltrates and large mediastinal lymph nodes.
- Bronchoscopy identified diffuse nodular lesions in the bilateral endobronchial tree.
Findings:
- Bronchial mucosal biopsy confirmed B-cell lymphoma.
- The patient received the R-CHOP chemotherapy regimen.
- Significant resolution of endobronchial and pulmonary lesions was observed post-treatment.
Implications:
- This case underscores the importance of considering rare diagnoses in persistent respiratory symptoms.
- Successful treatment with R-CHOP suggests its efficacy in managing endobronchial Non-Hodgkin lymphoma.
- Further research into endobronchial lymphoma presentations and treatment outcomes is warranted.
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