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Altered Thiol-Disulfide Homeostasis in Sarcoidosis: A Case-Control Study
Esma Andac Uzdogan1, Zeynep Hande Kocaer2, Salim Neselioglu1,3
1Department of Medical Biochemistry, Ankara Bilkent City Hospital, 06800 Ankara, Turkey.
Medicina (Kaunas, Lithuania)
|July 28, 2026
Summary
Dynamic thiol-disulfide homeostasis (TDH) is altered in sarcoidosis patients, indicating a shift towards oxidative stress. TDH parameters may serve as biochemical markers for this systemic redox imbalance.
Area of Science:
- Biochemistry
- Immunology
- Clinical Medicine
Background:
- Sarcoidosis is a multisystem inflammatory disease.
- Oxidative stress is a significant factor in sarcoidosis pathophysiology.
- Dynamic thiol-disulfide homeostasis (TDH) reflects systemic redox status.
Purpose of the Study:
- To evaluate TDH in patients with sarcoidosis.
- To determine if TDH parameters can differentiate sarcoidosis patients from healthy individuals.
- To assess the association between TDH and sarcoidosis.
Main Methods:
- Cross-sectional study of 58 sarcoidosis patients and 53 healthy controls.
- Automated spectrophotometric measurement of native thiol (NT) and total thiol (TT) concentrations.
- Calculation of disulfide (DS) levels and ratios; ROC and Cohen's d analysis.
Main Results:
- Sarcoidosis patients showed significantly lower serum NT and TT levels (p=0.003, p=0.009).
- Elevated DS levels and DS/NT ratio were observed in sarcoidosis patients (p=0.011, p<0.001).
- TDH parameters demonstrated association with sarcoidosis presence (AUC 0.625-0.664), with DS/NT ratio showing highest utility.
Conclusions:
- TDH is significantly altered in sarcoidosis, indicating a systemic shift towards an oxidative state.
- TDH parameters are potential exploratory biochemical indicators of systemic redox imbalance in sarcoidosis.
- Further large-scale prospective trials are needed to elucidate TDH's role in sarcoidosis pathophysiology.
