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Related Experiment Video

Updated: May 16, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Occam's razor or Hickam's dictum?

Nishant Gupta¹, Alejandro Aragaki, Kathryn A Wikenheiser-Brokamp

¹Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati, Cincinnati, OH, USA. guptans@ucmail.uc.edu

Journal of Bronchology & Interventional Pulmonology

|December 5, 2012

Summary

Sarcoidosis and histoplasmosis share similar symptoms, making diagnosis challenging. This case highlights histoplasmosis potentially preceding or triggering sarcoidosis development.

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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Published on: October 13, 2018

Area of Science:

Pulmonology
Infectious Diseases
Immunology

Background:

Sarcoidosis is a multisystemic inflammatory disease of unknown etiology, commonly affecting the lungs with non-necrotizing granulomas.
Histoplasmosis, a fungal infection caused by Histoplasma capsulatum, also primarily affects the lungs, typically presenting with necrotizing granulomas.

Observation:

A young male patient presented with clinical and radiographic features that initially suggested a difficult differentiation between sarcoidosis and histoplasmosis.
The patient was found to have histopathologic evidence of histoplasmosis.

Findings:

Following the diagnosis of histoplasmosis, the patient subsequently developed sarcoidosis.
This case demonstrates the potential for histoplasmosis to be a precursor or contributing factor in the development of sarcoidosis.

Implications:

The overlapping clinical and radiographic presentations of sarcoidosis and histoplasmosis necessitate careful diagnostic evaluation.
Further research is warranted to explore the potential role of Histoplasma capsulatum infection as an etiologic agent in sarcoidosis pathogenesis.