Synthesis and cytotoxicity of (+/-)-7,9-dideoxy-pancratistatin analogues
Olaia Nieto-García1, Ricardo Alonso
1Department of Organic Chemistry, University of Santiago de Compostela, Campus Vida, 15782 Santiago de Compostela, Spain. olaia.nieto@fu-berlin.de
Organic & Biomolecular Chemistry
|December 5, 2012
Abstract:
Access to some 7,9-dideoxy analogues of pancratistatin was achieved by combining our previously reported nitroenal/dioxanone annulation (to form ring C) with a hetero-Diels-Alder/aromatization path to build the dihydroisoquinolinone subunit (rings A and B); testing of their antiproliferative activity afforded some clues about the role of aromatic substituents in pancratistatin's pharmacophore.
