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Related Experiment Video

Updated: May 16, 2026

Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography
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Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography

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Microfluidic devices for X-ray studies on hydrated cells.

Britta Weinhausen1, Sarah Köster

  • 1Institute for X-Ray Physics & Courant Research Centre Nano-Spectroscopy and X-Ray Imaging, Georg-August-Universität Göttingen, Friedrich-Hund-Platz 1, 37077 Göttingen, Germany.

Lab on a Chip
|December 5, 2012
PubMed
Summary
This summary is machine-generated.

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New X-ray compatible microfluidic devices enable molecular-level cell analysis. These devices use novel materials for precise cellular structure studies using X-ray diffraction.

Area of Science:

  • Biophysics
  • Materials Science
  • Cell Biology

Background:

  • X-ray studies offer molecular-level insights into cellular structures.
  • Microfluidic devices provide controlled environments for cell analysis.
  • Existing devices often lack compatibility with X-ray techniques and cell culture.

Purpose of the Study:

  • To develop novel X-ray compatible microfluidic devices for biological cell studies.
  • To enable precise probing of cellular structures using X-ray scattering.
  • To facilitate X-ray diffraction experiments on cells within microfluidic systems.

Main Methods:

  • Fabrication of microfluidic devices using UV-curable adhesive.
  • Integration of Kapton films and silicon nitride membranes as cell substrates and X-ray windows.

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Soft Lithographic Procedure for Producing Plastic Microfluidic Devices with View-ports Transparent to Visible and Infrared Light

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Related Experiment Videos

Last Updated: May 16, 2026

Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography
11:48

Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography

Published on: April 24, 2018

A Microfluidic Device with Groove Patterns for Studying Cellular Behavior
13:50

A Microfluidic Device with Groove Patterns for Studying Cellular Behavior

Published on: August 30, 2007

Soft Lithographic Procedure for Producing Plastic Microfluidic Devices with View-ports Transparent to Visible and Infrared Light
10:26

Soft Lithographic Procedure for Producing Plastic Microfluidic Devices with View-ports Transparent to Visible and Infrared Light

Published on: August 17, 2017

  • Performance of scanning X-ray diffraction experiments with a nano-focused beam on fixed cells.

    • Main Results:

    • Successfully developed X-ray compatible microfluidic devices.
    • Demonstrated the use of UV-curable adhesive, Kapton, and silicon nitride for device fabrication.
    • Achieved scanning X-ray diffraction on fixed cells in buffer solution within the devices.

    Conclusions:

    • The developed microfluidic devices are suitable for X-ray studies of biological cells.
    • These devices offer a platform for molecular-level analysis of cellular structures.
    • The technology holds potential for in-situ X-ray studies on living cells.