Related Experiment Video
Updated: May 16, 2026
04:35
Using the Endoscope for Endobronchial Ultrasound in the Esophagus
Published on: November 21, 2023
Chronic eosinophilic pneumonia with endobronchial involvement.
Johsuke Hara1, Kouichi Nishi, Yoshiki Demura
1*Department of Respiratory Medicine †Department of Pathology, Ishikawa Prefectural Central Hospital ‡Department of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan.
Journal of Bronchology & Interventional Pulmonology
|December 5, 2012
Summary
This case study details chronic eosinophilic pneumonia (CEP) with rare endobronchial involvement. The findings highlight CEP
Area of Science:
- Pulmonology
- Respiratory Medicine
- Pathology
Background:
- Chronic eosinophilic pneumonia (CEP) is an idiopathic interstitial pneumonia.
- Endobronchial involvement in CEP is uncommon.
- Prompt diagnosis and treatment are crucial for managing CEP.
Purpose of the Study:
- To report a rare case of chronic eosinophilic pneumonia with significant endobronchial involvement.
- To describe the clinical, radiological, and pathological findings of this rare presentation.
- To emphasize the importance of considering endobronchial disease in CEP.
Main Methods:
- Case report of a 59-year-old male patient.
- Chest X-ray and computed tomographic (CT) scan of the chest.
- Bronchoalveolar lavage (BAL) fluid analysis.
- Bronchoscopy with biopsy of endobronchial nodules.
- Histopathological examination of bronchial wall nodules.
Main Results:
- Patient presented with fever, cough, wheezing, and dyspnea.
- Radiological findings included bilateral ground-glass opacities and tram track shadows.
- CT scan revealed bronchial wall thickening and centrilobular nodules.
- Marked eosinophilia was observed in peripheral blood and BAL fluid.
- Bronchoscopy identified white nodules in the right and left S bronchi.
- Histology confirmed eosinophilic inflammation within the bronchial walls.
Conclusions:
- This case represents a rare manifestation of chronic eosinophilic pneumonia with direct endobronchial involvement.
- Endobronchial nodules in CEP can be attributed to eosinophilic inflammation of the bronchial wall.
- The findings underscore the need for thorough bronchoscopic evaluation in suspected CEP cases with atypical features.
Related Concept Videos
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
01:23Chronic Obstructive Pulmonary Disease II: Emphysema
Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
01:19Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations
Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
01:23Chronic Obstructive Pulmonary Disease I: Introduction
Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
01:24Chronic Obstructive Pulmonary Disease
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.