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Related Experiment Video

Updated: May 16, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

Synaptic tagging and capture in the living rat.

K L Shires1, B M Da Silva, J P Hawthorne

  • 1Centre for Cognitive and Neural Systems (CCNS), University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, UK.

Nature Communications
|December 6, 2012
PubMed
Summary

Synaptic tagging and capture stabilizes memory in the brain. This process, observed in rats, shows how past and future neural activity shapes long-term memory persistence.

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Related Experiment Videos

Last Updated: May 16, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

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Published on: September 4, 2015

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Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals
08:38

Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals

Published on: May 25, 2011

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Memory Research

Background:

  • Long-term potentiation (LTP) is a key mechanism for memory formation.
  • Synaptic plasticity, the ability of synapses to strengthen or weaken over time, is crucial for learning.
  • Protein synthesis is essential for the consolidation of late-phase LTP.

Purpose of the Study:

  • To investigate whether synaptic tagging and capture occurs in vivo.
  • To determine if synaptic tagging and capture can stabilize or induce late- LTP in an intact animal.
  • To explore the role of past and future neuronal activity in synaptic change persistence.

Main Methods:

  • Experiments were conducted on intact rats.
  • Early LTP was induced using weak tetanization in hippocampal CA1 neurons.
  • Protein synthesis was inhibited to assess the conditions for late LTP induction and stabilization.

Main Results:

  • Synaptic tagging and capture was demonstrated in vivo in the rat hippocampus.
  • Late LTP could be induced during protein synthesis inhibition if an independent input was tetanized beforehand.
  • Declining early LTP was converted to lasting late LTP by subsequent strong tetanization of a separate input.

Conclusions:

  • Synaptic tagging and capture is not exclusive to in vitro preparations.
  • Neuronal activity history critically influences the persistence of synaptic modifications in living animals.
  • This phenomenon bridges cellular mechanisms of synaptic potentiation and behavioral memory.