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Liver glutathione contents in patients with gastric adenocarcinomas
1Department of Surgery, Faculty of Medicine, Gazi University, Ankara, Turkey.
Abstract:
Many antineoplastic agents alter the reduced glutathione (GSH) status of liver and tumor tissue by inhibiting cellular GSH-linked enzymes. Thus, intracellular GSH plays an important role in a wide variety of antineoplastic interventions regarding therapeutic efficacy and toxicity. Mean GSH values were 0.791 +/- 0.072 mg/m wet weight (ww) and 0.719 +/- 0.047 mg/g ww in gastric cancer tissue and nontumorous glandular mucosa, respectively. Whereas, the average GSH level of normal gastric mucosa was 1.709 +/- 0.135 mg/g, the mean GSH level of normal liver biopsies was 2.378 +/- 0.260 mg/g. The GSH values of normal liver tissue were higher than the hepatocellular GSH concentrations of patients with gastric adenocarcinoma and of another group of tumor-bearing patients who had received chemotherapy preoperatively. These results suggest that the GSH levels of tumor and liver may influence the efficacy and/or toxicity of chemotherapeutic agents.
Insights
Reduced glutathione (GSH) levels in liver and gastric cancer tissues impact chemotherapy effectiveness and side effects. Monitoring GSH may optimize antineoplastic treatments.
Area of Science:
- Biochemistry
- Oncology
- Pharmacology
Background:
- Antineoplastic agents often modulate cellular glutathione (GSH) levels by inhibiting GSH-linked enzymes.
- Intracellular GSH is crucial for the therapeutic efficacy and toxicity of various antineoplastic interventions.
Purpose of the Study:
- To investigate the role of reduced glutathione (GSH) levels in gastric cancer and liver tissues.
- To determine the relationship between GSH levels and the efficacy/toxicity of chemotherapy.
Main Methods:
- Quantification of mean GSH values in gastric cancer tissue, nontumorous glandular mucosa, normal gastric mucosa, and normal liver biopsies.
- Comparison of GSH levels between different tissue types and patient groups (gastric adenocarcinoma, chemotherapy-treated patients).
Main Results:
- Mean GSH values were 0.791 mg/g ww in gastric cancer and 0.719 mg/g ww in nontumorous glandular mucosa.
- Normal gastric mucosa had an average GSH level of 1.709 mg/g, while normal liver biopsies showed a mean of 2.378 mg/g.
- Hepatocellular GSH concentrations were lower in gastric adenocarcinoma patients and chemotherapy-treated patients compared to normal liver tissue.
Conclusions:
- Reduced glutathione (GSH) levels in both tumor and liver tissues may influence the efficacy and toxicity of chemotherapeutic agents.
- These findings suggest that GSH status is a significant factor in cancer treatment outcomes.