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[Double photon absorptiometry in renal osteodystrophy].

P Lechleitner1, A Dienstl, C Watfah

  • 1Universitätsklinik für Innere Medizin, Innsbruck.

Wiener Klinische Wochenschrift
|March 2, 1990
PubMed
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Patients on maintenance hemodialysis show decreased bone mineral content (BMC), particularly in Ward's triangle. Chronic interstitial nephritis exacerbates bone density loss, suggesting early vitamin D therapy may be beneficial.

Area of Science:

  • Nephrology
  • Endocrinology
  • Bone Metabolism

Background:

  • Maintenance hemodialysis is associated with significant bone mineral loss.
  • Chronic kidney disease can lead to complex bone metabolic disturbances.

Purpose of the Study:

  • To assess bone mineral content (BMC) in patients undergoing maintenance hemodialysis.
  • To investigate the correlation between BMC, dialysis duration, and parathyroid hormone levels.
  • To evaluate changes in BMC over one year and identify risk factors for bone loss.

Main Methods:

  • Bone mineral content (BMC) was measured in the lumbar spine, femoral neck, Ward's triangle, and trochanteric region of 52 hemodialysis patients.
  • BMC was compared to sex- and age-matched normal values.
  • A subset of patients underwent a second BMC measurement after one year.

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Main Results:

  • Overall, a significant decrease in BMC was observed only in Ward's triangle.
  • Patients with chronic interstitial nephritis showed significant bone density reduction in Ward's triangle and the trochanteric region.
  • BMC did not correlate with dialysis duration or intact parathyroid hormone levels.
  • A slight fall in lumbar spine and Ward's triangle BMC was noted after one year, with a pronounced fall in the trochanteric region.

Conclusions:

  • Hemodialysis patients exhibit reduced bone mineral content, especially in specific skeletal sites.
  • Chronic interstitial nephritis is linked to more severe bone demineralization.
  • Early, monitored therapy with vitamin D metabolites may help mitigate bone loss in this population.